Kirihito Osanai, a young doctor with a prestigious university hospital, is deeply engaged in the study of Monmow Disease, an endemic condition that has overtaken the remote village of Doggodale. The disease reshapes the skeleton of its victims until they resemble dog-like creatures, ultimately resulting in death. Though Kirihito's superior, Dr. Tatsugaura, has banked his career on Monmow being caused by a contagious pathogen, Kirihito believes it is an organic disease--a belief shared by his old friend and colleague, Dr. Urabe.